Requirement for Serine-384 in Caspase-2 processing and activity
نویسندگان
چکیده
منابع مشابه
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.
Activation of the cysteine protease Caspase-1 is a key event in the innate immune response to infections. Synthesized as a proprotein, Caspase-1 undergoes autoproteolysis within multiprotein complexes called inflammasomes. Activated Caspase-1 is required for proteolytic processing and for release of the cytokines interleukin-1β and interleukin-18, and it can also cause rapid macrophage cell dea...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2020
ISSN: 2041-4889
DOI: 10.1038/s41419-020-03023-6